The guidelines are directed mainly to veterinarians in both the private and governmental sectors. It provides the essential guiding aspects regarding correct decision making of the right choice of vaccines to be used in particular vaccination campaigns that fulfill the local animal health programs objectives. Designing of vaccination campaigns according to the existing challenges of the diseases in the area (initial and booster doses regimens) also discussed. An idea also is given about vaccines production and proper handling, correct usage and storage conditions. Pre and post vaccination animal care, and how to deal with vaccination side effects and post vaccination reactions are also explained.